Pancreatic xenograft survival in diabetic rabbits.
Artigo
em Inglês
| IMSEAR
| ID: sea-86934
ABSTRACT
Prolonged survival of pancreatic xenografts in the muscles of diabetic rabbits was achieved. The mean graft survival time (assessed by euglycemic status) in nonimmunosuppressed (Group A) was 10 days and in immunosuppressed (Group B) was 36 days (P < 0.05). Adequate immunosuppression helps pancreatic xenograft to normalize blood glucose level (BGL) by prolonging survival time. Our study demonstrates that xenotransplantation of islet cells in their natural environment (pancreatic tissue in four of thin slices) survive and function adequately in immunosuppressed recipients. This discordant Xenotransplantation model may be useful for future xenotransplantation studies.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Coelhos
/
Fatores de Tempo
/
Transplante Heterólogo
/
Glicemia
/
Cabras
/
Terapia de Imunossupressão
/
Transplante de Pâncreas
/
Diabetes Mellitus Experimental
/
Sobrevivência de Enxerto
/
Animais
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
1994
Tipo de documento:
Artigo
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