Plasma exchange for thrombotic thrombocytopenic purpura following hematopoietic stem cell transplantation.
Artigo
em Inglês
| IMSEAR
| ID: sea-87909
ABSTRACT
A 17 years old female diagnosed with acute myeloid leukemia (AML)-M2 received an allogeneic haematopoietic stem cell transplant (HSCT) and was given graft versus host disease (GVHD) prophylaxis with methotrexate, cyclosporin-A (CsA) and methyl prednisolone. On day +42 post-transplant, she was diagnosed to have thrombotic thrombocytopenic purpura (TTP). Therapeutic plasma exchange (TPE) (40 ml/kg body mass) using fresh frozen plasma was performed on 8 consecutive days. The renal function, LDH levels, platelet count and peripheral smear findings improved but the neurological symptoms persisted even after TPE. Few reports are available in literature on the effectiveness of therapeutic plasma exchange (TPE) in post-bone marrow transplant (BMT) TTP. The good hematologic response achieved in this patient suggests that TPE could be life-saving and should be tried in every patient with post-BMT TTP.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Troca Plasmática
/
Púrpura Trombocitopênica Trombótica
/
Feminino
/
Humanos
/
Leucemia Mieloide
/
Doença Aguda
/
Adolescente
/
Transplante de Células-Tronco Hematopoéticas
Idioma:
Inglês
Ano de publicação:
2005
Tipo de documento:
Artigo
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