Effects of commonly used NSAID's on gastric mucosa. A clinico-endoscopic and histopathological study.
Artigo
em Inglês
| IMSEAR
| ID: sea-89428
ABSTRACT
Non steroidal anti-inflammatory drugs (NSAID's) are one of the most commonly used agents in clinical practice today. All these drugs are known to produce gastro-intestinal lesions. In the present study we found that aspirin, indomethacin and phenylbutazone caused gastric mucosal damage in 90.9%, 100%, respectively while ibuprofen and paracetamol caused gastric mucosal damage in 33.3% and 37.5% respectively. Thus latter two drugs were safer NSAID's. Further more we have demonstrated that endoscopic monitoring of the patients on NSAID's is a sensitive method of early detection of gastric mucosal damage. This monitoring may be particularly valuable in high risk subjects on NSAID's.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Oxifenilbutazona
/
Anti-Inflamatórios não Esteroides
/
Aspirina
/
Ibuprofeno
/
Indometacina
/
Adolescente
Tipo de estudo:
Estudo de rastreamento
Idioma:
Inglês
Ano de publicação:
1990
Tipo de documento:
Artigo
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