Food reduces isoniazid bioavailability in normal volunteers.
Artigo
em Inglês
| IMSEAR
| ID: sea-89466
ABSTRACT
Food and drug interaction is a major variable in bioavailability of drugs. Isoniazid is the most common antitubercular drug used in India. We studied the effect of standard Indian breakfast and lunch on the bioavailability of isoniazid in a single dose crossover study in normal male volunteers. The standard breakfast and lunch significantly reduced plasma AUC, Cmax and Kabs values of isoniazid. Isoniazid, thus, should not be administered with food.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Masculino
/
Disponibilidade Biológica
/
Adulto
/
Alimentos
/
Isoniazida
Idioma:
Inglês
Ano de publicação:
1991
Tipo de documento:
Artigo
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