Methotrexate: clinical and immunological effects in refractory rheumatoid arthritis.
Artigo
em Inglês
| IMSEAR
| ID: sea-90474
ABSTRACT
Thirty five patients with refractory rheumatoid arthritis were given 7.5 mg of methotrexate (Mtx) every week. Eleven patients had to discontinue treatment either because of adverse effects or unresponsiveness. Twenty four patients showed clinical response and significant improvement in ESR and they continued Mtx for a mean of 25.24 months. Seven patients achieved clinical remission as defined by ARA criteria. Immunological parameeters including IgG, IgM, IgA, lymphocyte subsets (CD3+, CD4+, CD8+ and B), C3 and C4 however, did not show any change during this treatment in any of the groups upto 6 months. There was a significant fall in the erythrocyte sedimentation rate (ESR), c-reactive protein (CRP) and rheumatoid factor (RF) levels in responders only.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Artrite Reumatoide
/
Vômito
/
Sedimentação Sanguínea
/
Indução de Remissão
/
Feminino
/
Humanos
/
Masculino
/
Metotrexato
/
Administração Oral
/
Estudos Prospectivos
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
1992
Tipo de documento:
Artigo
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