Hematopoietic growth factors in drug-induced agranulocytosis.
Artigo
em Inglês
| IMSEAR
| ID: sea-90702
ABSTRACT
Drug-induced agranulocytosis (DIA) is a potentially fatal disorder. Hematopoietic growth factors have been used in the treatment of DIA. We report nine cases of DIA treated with granulocyte macrophage - colony stimulating factor (GM-CSF) in a dose of 300 microg/day. All the patients had evidence of systemic infection. Mean time to reach an absolute neutrophil count of 0.5 x 10(9)/L was three days. One patient succumbed to the disease. The cause of death was multiorgan failure. No adverse events were observed with GM-CSF. We conclude that hematopoietic growth factors are useful in shortening the period of neutropenia and reducing morbidity and mortality in these patients.
Texto completo:
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Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Sulfassalazina
/
Feminino
/
Humanos
/
Masculino
/
Clorpromazina
/
Dipirona
/
Estudos Retrospectivos
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
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Adolescente
/
Resultado do Tratamento
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Ano de publicação:
2002
Tipo de documento:
Artigo
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