Interleukin-2 as a therapeutic agent.
Artigo
em Inglês
| IMSEAR
| ID: sea-91438
ABSTRACT
Interleukin-2 (IL-2) belongs to a class of soluble, regulatory proteins known as cytokines. It is a 133 amino acid glycoprotein secreted by T(H) lymphocytes and other cells following activation by antigens, mitogens and other cytokines. It stimulates the proliferation and cytotoxicity of T lymphocytes. It also enhances the microbicidal and cytotoxic activities of NK cells, B lymphocytes, macrophages and monocytes. IL-2 can now be produced in unlimited quantities by recombinant DNA technology and used therapeutically to modulate the immune system in a number of diseases. A number of different studies have demonstrated its therapeutic value in HIV +ve and AIDS patients. It has been approved by US-FDA for treatment of metastatic renal cell carcinoma (RCC) and metastatic melanoma. Routine detection of soluble IL-2 receptor in blood could be useful as a diagnostic marker in some autoimmune diseases. Agents that antagonize IL-2 find application as immunosuppressants. The main adverse effect of IL-2 is capillary leak syndrome caused by increased capillary permeability and extravasation of fluid. In days to come, IL-2 is likely to play an increasingly important role in management of viral infections, malignancies and a number of other diseases conditions.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Infusões Intravenosas
/
Humanos
/
Esquema de Medicação
/
Doenças Transmissíveis
/
Administração Oral
/
Ensaios Clínicos como Assunto
/
Sensibilidade e Especificidade
/
Interleucina-2
/
Resultado do Tratamento
/
Relação Dose-Resposta a Droga
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Ano de publicação:
2001
Tipo de documento:
Artigo
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