Dissociation of clinical and laboratory diagnosis in hypothyroidism.
Artigo
em Inglês
| IMSEAR
| ID: sea-91516
ABSTRACT
AIMS OF THE STUDY To assess the significance of clinical versus biochemical diagnosis of hypothyroidism using a clinical scoring index and optimize the therapeutic dose of levothyroxine in Indian patients. METHODOLOGY:
Three hundred and eighty eight cases of primary hypothyroidism (malefemale ratio 15.8) were clinically classified as hypothyroid, euthyroid or inconclusive by Billewicz score. TSH estimation was repeated at 6-8 week intervals and appropriate adjustments in levothyroxine dosage made till the TSH was within the normal range.RESULTS:
Of 388 biochemically confirmed hypothyroid subjects less than one fourth (21.6%) could be classified as hypothyroid, almost one half were euthyroid (48.4%) and the remaining (29.9%) fell in the inconclusive category according to Billewiz score. Of 227 patients who returned for complete follow up there was a positive correlation of replacement dose with age and initial weight in females, but not in males. Baseline TSH values were not found to have a significant correlation with the initial dose. The mean replacement dose of levothyroxine (T4) in our subjects was 109.4 +/- 24.05 microg/d (range 1.25-3.84 microg/kg).CONCLUSION:
Clinical parameters alone fare poorly in establishing an unequivocal diagnosis of hypothyroidism. A biochemical confirmation is mandatory. The replacement done of T4 was found to be independent of the basal TSH level.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Valores de Referência
/
Testes de Função Tireóidea
/
Hormônios Tireóideos
/
Tiroxina
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Recém-Nascido
/
Tireotropina
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Ano de publicação:
2005
Tipo de documento:
Artigo
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