Rapid immunodiagnosis of active cytomegalovirus infection by pp65 antigenemia assay.
Bangladesh Med Res Counc Bull
;
2006 Apr; 32(1): 22-8
Artigo
em Inglês
| IMSEAR
| ID: sea-92
ABSTRACT
Detection of early antigen PP65 in blood leucocytes is a new method of diagnosing active cytomegalovirus (CMV) infection. Using a mixture of two monoclonal antibodies, CMV pp65 antigen was detected in blood leucocytes by a quantitative indirect immunofluorescence test within 3-5 hours after sampling. The pp65 antigen was detected in 20(29.8%) of the 67 immunocompromised patients included in this study. The level of CMV antigenemia appears to be related to the severity of CMV infection. Thus, this method may provide a rapid and sensitive approach to early diagnosis of active CMV infection in immunocompromised patients and a promising marker for initiating therapy and monitoring disease activity and its response to therapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfoproteínas
/
Bangladesh
/
Testes Imunológicos
/
Humanos
/
Proteínas da Matriz Viral
/
Infecções por Citomegalovirus
/
Diagnóstico Precoce
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Bangladesh Med Res Counc Bull
Ano de publicação:
2006
Tipo de documento:
Artigo
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