Glucagon response to glucose load in offspring of conjugal type 2 diabetic parents in south India.
Artigo
em Inglês
| IMSEAR
| ID: sea-93163
ABSTRACT
Immunoreactive glucagon responses were measured in 21 normoglycaemic adult offspring of non-insulin dependent (Type 2) diabetic parents, in the fasting state and during an oral glucose tolerance test. In 7 of the 21 offspring, the mean fasting immunoreactive glucagon value was significantly lower than the control value (p < 0.001). In this group, glucose stimulation did not produce inhibition of immunoreactive glucagon secretion. The insulin response in this group was not significantly different from the values in the other study groups. In the other 14 offspring, the pattern of glucagon response to glucose stimulation was similar to controls. It is likely that this non-suppressive effect of glucose on immunoreactive glucagon in some of the "prediabetic" individuals is an early change in the alpha cell function during the natural history of non-insulin dependent diabetes in Asian Indian subjects.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Glicemia
/
Feminino
/
Humanos
/
Masculino
/
Glucagon
/
Análise de Variância
/
Adulto
/
Diabetes Mellitus Tipo 2
/
Teste de Tolerância a Glucose
/
Índia
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
1992
Tipo de documento:
Artigo
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