Danazol in Indian haemophiliacs.
Artigo
em Inglês
| IMSEAR
| ID: sea-93173
ABSTRACT
Danazol, 10 mg/kg/day (maximum 600 mg/day) was given in two divided doses for 14 days in 30 patients with haemophilia-A. Rise in factor-VIII level was observed in all the patients after one week of danazol therapy, irrespective of initial factor-VIII Levels. In haemophiliacs with less than 1% factor VIII level, rise was maximum (3-6 folds); mean factor-VIII level at 7th and 14th day of danazol therapy was 2.3 +/- 0.6% and 4.8 +/- 1.1%, respectively. Only marginal increase in factor-VIII was noted in haemophiliacs with initial factor-VII levels more than 3%. The raised level of factor-VIII persisted after stopping the therapy during the observation period of 2 more weeks, irrespective of initial levels. No adverse effect was observed during or after.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Transfusão de Sangue
/
Humanos
/
Masculino
/
Fator VIII
/
Adolescente
/
Adulto
/
Danazol
/
Hemofilia A
/
Índia
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
1993
Tipo de documento:
Artigo
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