NSAIDs and kidney.
Artigo
em Inglês
| IMSEAR
| ID: sea-93716
ABSTRACT
NSAIDs are commonly used drugs. Even with the advent of selective COX-2 inhibitors, nephrotoxicity still remains a concern. The adverse effects of NSAIDs are mediated via inhibition of prostaglandin synthesis from arachidonic acid by non-specific blocking of the enzyme cyclooxygenase leading to vasoconstriction and reversible mild renal impairment in volume contracted states. When unopposed, this may lead to acute tubular necrosis and acute renal failure. NSAIDs also produce interstitial nephritis with or without nephrotic syndrome secondary to minimal change disease. Although this presents as acute renal failure, it can progress in some cases to chronic renal failure. Papillary necrosis has been incriminated in the development of chronic renal failure secondary to NSAIDs. In patients on long term NSAIDs without acute or chronic renal failure, subclinical renal dysfunction such as reduced creatinine clearance and impaired urine concentrating ability has been shown to be present. Although this sub-clinical dysfunction is reversible on withdrawal of NSAIDs, some reports have suggested a persistent residual dysfunction. Even with a wide range of NSAIDs at our disposal, a renal safe NSAID is yet to be discovered.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Feminino
/
Humanos
/
Masculino
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Anti-Inflamatórios não Esteroides
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Incidência
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Medição de Risco
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Relação Dose-Resposta a Droga
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Injúria Renal Aguda
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Falência Renal Crônica
Tipo de estudo:
Estudo de etiologia
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Estudo de incidência
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Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Ano de publicação:
2004
Tipo de documento:
Artigo
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