Kidney functions in newly diagnosed type 2 diabetic subjects: role of glycemic control.
Artigo
em Inglês
| IMSEAR
| ID: sea-93794
ABSTRACT
BACKGROUND:
The increased urinary albumin excretion (UAE) found at the diagnosis in type 2 diabetes may at least be functional and, thus reversible, as in type 1 diabetes. Furthermore, a positive correlation has been found between the glycemic control and UAE in type 2 diabetic subjects. MATERIAL ANDMETHODS:
The impact of glycemic control after achieving three months of continuous normo-glycemia was studied in 26 (including 16 males and 10 females) newly diagnosed type 2 diabetic patients to assess renal size/volumes, various renal functions and UAE.RESULTS:
A significant reduction was seen in glomerular filtration rate (GFR), UAE and fractional albumin clearance after achieving near normoglycemia (p < 0.01). A decrease in the kidney size/volume, though statistically insignificant, was also observed. Besides a decline in GFR of 4.8% was also noted after three months of stable normoglycemia. UAE normalized in six of these subjects. A statistically significant correlation was also found between the changes in mean fasting plasma glucose and the decline in UAE (r=0.56 and p < 0.01).CONCLUSION:
The study emphasizes the necessity to correct the apparently reversible increase in microabuminuria that accompanies hyperglycemia prior to patients recruitment for intervention therapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Glicemia
/
Feminino
/
Humanos
/
Masculino
/
Análise de Variância
/
Diabetes Mellitus Tipo 1
/
Albuminúria
/
Taxa de Filtração Glomerular
/
Hiperglicemia
/
Rim
Idioma:
Inglês
Ano de publicação:
2002
Tipo de documento:
Artigo
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