Gabapentin in the management of pentazocine dependence: a potent analgesic--anticraving agent.
Artigo
em Inglês
| IMSEAR
| ID: sea-94001
ABSTRACT
OBJECTIVES:
To evaluate the role of Gabapentin in the management of Pentazocine dependence for suppressing muscle aching and craving during its withdrawal. MATERIAL ANDMETHODS:
Patients of Pentazocine dependence were divided in two groups GpA and GpB (n = 10 in each) and were administered Clonidine (P.O.) in first seven days (acute detoxification phase) and later Naltrexone (P.O.) from seventh day onwards (stabilisation-maintenance phase). Gabapentin (1200 mg/day) was additionally added in group B. Muscle pain and craving were rated on 100 mm visual-analogue scale. Psychological dependence was assessed on four step categorical scale.RESULTS:
Group B (Gabapentin group) scored significantly lower (p < 0.001) than group A on both the parameters. Psychological dependence was significantly low (p < 0.01) in Gabapentin group.CONCLUSION:
Gabapentin is an important adjuvant to the management of opiate dependence both in acute detoxification as well as stabilisation phase.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Dor
/
Pentazocina
/
Síndrome de Abstinência a Substâncias
/
Ansiolíticos
/
Feminino
/
Humanos
/
Masculino
/
Clonidina
/
Transtornos Relacionados ao Uso de Substâncias
/
Ácidos Cicloexanocarboxílicos
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Ano de publicação:
2003
Tipo de documento:
Artigo
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