Clinical applications of molecular haematology: flow cytometry in leukaemias and myelodysplastic syndromes.
Artigo
em Inglês
| IMSEAR
| ID: sea-94035
ABSTRACT
Flow cytometry is semi-automated study of antigen profile of cells using the Scatchard principle of antigen-antibody binding and fluorochrome-based detection systems. Flow cytometric evaluation of cellular proteomics has become an integral part of the laboratory diagnosis and classification of haematopoietic neoplasms. Recent technical advances in lasers, monoclonal antibodies, fluorochromes, and computer-based color compensation algorithms have expanded the usefulness of flow cytometry. Detection of minimal residual disease by flow cytometry in leukaemias and lymphomas is incorporated in many treatment protocols. Finding of aberrant maturation pattern of granulocytes offers a sensitive screening tool for early diagnosis of myelodysplastic syndromes. Detailed proteomic analysis of leukemias is helping more precise prognostic and biological stratification.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Síndromes Mielodisplásicas
/
Humanos
/
Leucemia
/
Doença Aguda
/
Proteômica
/
Citometria de Fluxo
/
Hematologia
/
Transtornos Mieloproliferativos
Tipo de estudo:
Guia de Prática Clínica
/
Estudo prognóstico
/
Estudo de rastreamento
Idioma:
Inglês
Ano de publicação:
2007
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS