Neuroprotective agents in acute ischemic stroke.
Artigo
em Inglês
| IMSEAR
| ID: sea-94502
ABSTRACT
The concept of neuroprotection relies on the principle that delayed neuronal injury occurs after ischemia. The phenomenon of the "ischemic cascade" has been described, and each step along this cascade provides a target for therapeutic intervention. A wide variety of drugs have been studied in humans. Ten classes of neuroprotective agents have reached phase III efficacy trials but have shown mixed results. They included calcium channel antagonists, NMDA receptor antagonists, lubeluzole, CDP-choline, the free radical scavenger tirilazad and ebselen, enlimomab, GABA agonist clomethiazole, the sodium channel antagonist fosphenytoin, magnesium, glycine site antagonist GV150526 and piracetam. Furthermore, the mechanisms that underlie the development of focal ischemic injury continue to be discovered, opening new therapeutic perspective for neuroprotection that might clinically be applicable in the future.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ácidos Pipecólicos
/
Piperidinas
/
Quinoxalinas
/
Ratos
/
Tiazóis
/
Idoso
/
Humanos
/
Bloqueadores dos Canais de Cálcio
/
Traumatismo por Reperfusão
/
Clormetiazol
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS