HLA genotyping in type-I autoimmune hepatitis in Western India.
Artigo
em Inglês
| IMSEAR
| ID: sea-94562
ABSTRACT
OBJECTIVES:
To analyze association of different HLA genotypes for predisposition to type-I autoimmune hepatitis in Western India.METHODS:
This study was undertaken on patients of type-I autoimmune hepatitis (defined by international criteria by IAHG, 1999). HLA genotyping for class I and II was done in 20 patients of autoimmune hepatitis and 100 healthy controls. Statistics were done using Halden's modification of Woolfs formula.RESULT:
Significant association of autoimmune hepatitis was found amongst class I antigens--HLA B27 [20 vs. 0 %] & HLA cw4 [40 vs. 15 %] and amongst class II antigens--DRBI*01XX [25 vs. 2%], DRB1*14XX [30 vs. 12%], DRB1*15XX [40 vs. 25%] and DRB1*07XX [20 vs. 9 %] at DRB1 locus. Stronger association was found with HLA B27, cw4 & HLA DRB1 *01XX.CONCLUSION:
Our data indicate that predisposition to autoimmune hepatitis is different in Indian patients and not associated with HLA DRB1*03XX or *04XX, as seen in Western world.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Adolescente
/
Adulto
/
Hepatite Autoimune
/
Predisposição Genética para Doença
/
Frequência do Gene
/
Genótipo
/
Antígenos HLA
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2003
Tipo de documento:
Artigo
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