Do side-effects reduce compliance to iron supplementation? A study of daily- and weekly-dose regimens in pregnancy.
J Health Popul Nutr
;
2002 Jun; 20(2): 175-9
Artigo
em Inglês
| IMSEAR
| ID: sea-976
ABSTRACT
Side-effects of iron supplementation lead to poor compliance. A weekly-dose schedule of iron supplementation rather than a daily-dose regimen has been suggested to produce fewer side-effects, thereby achieving a higher compliance. This study compared side-effects of iron supplementation and their impact on compliance among pregnant women in Bangladesh. These women were assigned to receive either weekly doses of 2 x 60 mg iron (one tablet each Friday morning and evening) or a daily dose of 1 x 60 mg iron. Fifty antenatal care centres were randomly assigned to prescribe either a weekly- or a daily-supplementation regimen (86 women in each group). Side-effects were assessed by recall after one month of supplementation and used for predicting compliance in the second and third months of supplementation. Compliance was monitored using a pill bottle equipped with an electronic counting device that recorded date and time whenever the pill bottle was opened. Of five gastrointestinal side-effects (heartburn, nausea, vomiting, diarrhoea, or constipation) assessed, vomiting occurred more frequently in the weekly group (21%) than in the daily group (11%, p<0.05). Compliance (ratio between observed and recommended tablet intake) was significantly higher in the weekly-supplementation regimen (93%) than in the daily-supplementation regimen (61%, p<0.05). Overall, gastrointestinal side-effects were not significantly associated with compliance. However, the presence of nausea and/or vomiting reduced compliance in both the regimens-but only among women from the lower socioeconomic group. In conclusion, weekly supplementation of iron in pregnancy had a higher compliance compared to daily supplementation of iron despite a higher frequency of side-effects. The findings support the view that gastrointestinal side-effects generally have a limited influence on compliance, at least in the dose ranges studied. Efforts to further reduce side-effects of iron supplementation may not be a successful strategy for improving compliance and effectiveness of antenatal iron supplementation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Complicações Hematológicas na Gravidez
/
Fatores Socioeconômicos
/
Bangladesh
/
Feminino
/
Humanos
/
Gravidez
/
Esquema de Medicação
/
Cooperação do Paciente
/
Anemia Ferropriva
/
Suplementos Nutricionais
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
J Health Popul Nutr
Assunto da revista:
Gastroenterology
/
Nutritional Sciences
/
Public Health
Ano de publicação:
2002
Tipo de documento:
Artigo
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