A case of acute kidney injury caused by dapsone-induced methemoglobinemia in a patient with chronic kidney disease
Journal of the Korean Society of Emergency Medicine
;
: 379-382, 2023.
Artigo
em Inglês
| WPRIM
| ID: wpr-1001852
ABSTRACT
Methemoglobinemia (MetHb), which is characterized by an increased methemoglobin level, is a rare but potentially fatal disorder caused by congenital enzyme deficiencies or exposure to oxidizing agents, including dapsone. Elevation in the methemoglobin level impairs the oxygen-carrying capacity of hemoglobin, produces functional anemia, and induces tissue hypoxia. Such hypoxia results in microcirculation injury and hypoperfusion in the tissue and organs, including the kidney, and is a risk factor for acute kidney injury (AKI). This paper reports a case of AKI caused by dapsone-induced MetHb in a patient with chronic kidney disease, in which the patient ingested approximately 1,500 mg of dapsone in a suicide attempt, which was treated with aggressive management, including methylene blue, ascorbic acid, and transfusion.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Journal of the Korean Society of Emergency Medicine
Ano de publicação:
2023
Tipo de documento:
Artigo
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