The Effect of Preemptive Local Infiltration of Lidocaine and Gabapentin on Postoperative Pain in Rats / 대한마취과학회지
Korean Journal of Anesthesiology
; : 389-396, 2001.
Article
em Ko
| WPRIM
| ID: wpr-100267
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Preemptive analgesia may improve postoperative antinociceptive treatment that prevents the development of central sensitization which contributes to post-injury pain hypersensitivity. However, beneficial effects of preemptive analgesia appear controversial. The purpose of this study was to examine the effect of pre- and post-incisional local infiltration of lidocaine and gabapentin on incisional pain in rats. METHODS: Thirty five male rats were divided into 7 groups; control group (n = 5), pre-lidocaine infiltration group (n = 5), post-lidocaine infiltration group (n = 5), pre-gabapentin 10 mg infiltration group (n = 5), post-gabapentin 10 mg infiltration group (n = 5), pre-gabapentin 30 mg infiltration group (n = 5), and post-gabapentin 30 mg infiltration group (n = 5). To evaluate postoperative mechanical hyperalgesia in injured feet, withdrawal thresholds were measured by calibrated von Frey filaments at 2 hrs, 1, 2, 3, 4, and 5 days after an incision. RESULTS: The pre-lidocaine infiltration group shows better analgesic effects than post-lidocaine infiltration group until postoperative day 1 (P < 0.05). The gabapentin infiltration groups were effective in postoperative pain management but there were no significant differences between pre- and post- incisional treatment. CONCLUSIONS: A preemptive lidocaine injection has a good analgesic effect on incisional pain. Gabapentin also has a good analgesic effect on incisional pain.
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Assunto principal:
Dor Pós-Operatória
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Sensibilização do Sistema Nervoso Central
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Pé
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Hiperalgesia
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Analgesia
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Hipersensibilidade
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Lidocaína
Limite:
Animals
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Humans
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Male
Idioma:
Ko
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2001
Tipo de documento:
Article