The Effects of Desflurane on Ca2+ Release from the Myocardial Sarcoplasmic Reticulum in Vitro / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 376-383, 2001.
Artigo
em Coreano
| WPRIM
| ID: wpr-100269
ABSTRACT
BACKGROUND:
The purpose of this study is to examine the effect of Desflurane on myocardial contractility and cellular electrophysiologic behabior in isolated guinea pig and rat right ventricular papillary muscle.METHODS:
The isometric force of a guinea pig ventricular papillary muscle was studied in normal and 26 mM Tyrode's solution at various stimulation rates. Experiments using rat papillary muscles under normal Tyrode's solution at resting-state (RS) and using guinea pig papillary muscles under low Na Tyrode's solution (25 mM) were performed to evaluate the effect on Ca2+ release from the sarcoplasmic reticulum (SR). Normal and slow action potentials (APs) were evaluated by using a conventional microelectrode technique. Effects of desflurane on SR function in situ were examined by its effect on rapid colling contractures (RCCs). 1 MAC (end-tidal concentration 6%) and 2 MAC desflurane were applied.RESULTS:
Desflurane equivalent to 6% and 12% depressed guinea pig myocardial contractions in the control to -70% and -40% from RS to 3 Hz stimulation rates. Contractile force after rest in rat and guinea pig myocardium under low Na Tyrode's solution showed modest depression. In the partially depolarized, beta-adrenergically stimulated myocardium, 6% and 12% desflurane caused marked depression of late force (6% -60%, 12% -80%) with moderate changes of early peak force (6% -20%, 12% -40%). RCCs were abolished at 6% concentration.CONCLUSIONS:
The direct myocardial depressant effects of desflurane is slightly greater to those seen with isoflurane. The rapid initial release of Ca2+ from the SR by depolarization seems to be modestly depressed, although certain release pathways induced by rapid colling appear to be markedly depressed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Músculos Papilares
/
Retículo Sarcoplasmático
/
Potenciais de Ação
/
Contratura
/
Depressão
/
Cobaias
/
Isoflurano
/
Microeletrodos
/
Contração Miocárdica
/
Miocárdio
Limite:
Animais
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2001
Tipo de documento:
Artigo
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