The Prognostic Significance of Serum CA 125 Levels in Patients with Advanced Serous Epithelial Ovarian Cancer / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1132-1137, 2004.
Artigo
em Coreano
| WPRIM
| ID: wpr-100313
ABSTRACT
OBJECTIVE:
In this retrospective study, we analyzed the clinicopathologic characteristics of advanced serous epithelial ovarian cancer and evaluated the prognostic factors which have an impact on survival of patients with epithelial ovarian cancer. We also compared several analyzing methods of CA 125 for predicting prognosis of advanced serous epithelial ovarian cancer.METHODS:
A total of 57 patients with advanced serous epithelial ovarian cancer who were treated at Samsung Medical Center between Aug. 1995 and Jul. 2000 were included. Medical records including pathologic reports were reviewed to identify clinicopathologic characteristics and serum levels of CA 125. Five different methods of analyzing serum CA 125 were compared for predicting the prognosis of advanced serous epithelial ovarian cancer. Survival curves were analyzed by Kaplan-Meier method and Cox proportional hazards model.RESULTS:
The median age of all patients was 54.2 years. In univariate analysis, age, FIGO stage, grade, residual tumor and ascites showed no significant correlation with prognosis. Among five different analyzing methods of serum CA 125 levels, normalization after 3rd chemotherapy was correlated with improved 5-year survival rate (p=0.026).CONCLUSION:
This study showed that normalization of serum levels of CA 125 after 3rd chemotherapy is useful for predicting prognosis of advanced serous epithelial ovarian cancer patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Ovarianas
/
Prognóstico
/
Ascite
/
Modelos de Riscos Proporcionais
/
Prontuários Médicos
/
Taxa de Sobrevida
/
Estudos Retrospectivos
/
Neoplasia Residual
/
Tratamento Farmacológico
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2004
Tipo de documento:
Artigo
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