Maternal and neonatal outcomes among women with gestational diabetes mellitus treated with metformin in a tertiary hospital: A retrospective cohort study
Philippine Journal of Internal Medicine
;
: 215-220, 2023.
Artigo
em Inglês
| WPRIM
| ID: wpr-1003701
ABSTRACT
Background@#Gestational diabetes mellitus (GDM) is a common disorder associated with both maternal and fetal complications. Treatment for GDM requires lifestyle modification, as well as insulin and oral anti-diabetes medications to prevent unwarranted fetal and maternal outcomes.@*Objective@#To determine the feto-maternal outcomes of GDM patients treated with either metformin-monotherapy, insulin- monotherapy, and with insulin plus metformin (combination) therapy in a private tertiary hospital in Metro Manila.@*Methods@#This is a retrospective cohort study involving 209 GDM patients admitted from January 2017 to December 2019. Census and chart reviews were done for demographic and clinical data. These were divided into 3 groups metformin-monotherapy, insulin-monotherapy, and combination treated groups. Analysis of Variance was used to compare the average capillary blood glucose (CBG) levels of patients. Chi-square and Fisher’s Exact tests were used for nonparametric data.@*Results@#Birthweight was significant across all groups metformin-monotherapy group highest with large-for-gestational- age (LGA) at 25%, small-for-gestational-age (SGA) highest on the insulin-monotherapy group (11.3%) and appropriate-for- gestational-age (AGA) highest in the combination therapy group (84.6%). Age of gestation (AOG) at delivery (p=0.005), maternal CBG during labor (p=0.007), and chronic hypertension (p=0.001) were statistically significant across all groups. Multiple comparisons showed the following statistically significant results as well chronic hypertension between metformin and combination group (p <0.01), AOG during delivery between metformin vs insulin group (p=0.004), maternal CBGs during labor between metformin vs insulin group (p=0.022), and insulin vs combination treatment group (p=0.029). Average maternal CBG levels were also showed statistically significant difference between the metformin vs insulin group (p=0.029).@*Conclusion@#Metformin may be used in controlling CBG levels in GDM patients. Although metformin may be comparable to insulin, more long-term studies need to be done to determine its long-term effects on neonates.
Buscar no Google
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Diabetes Gestacional
Idioma:
Inglês
Revista:
Philippine Journal of Internal Medicine
Ano de publicação:
2023
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS