Discussion on the clinical non-transfusion application of platelet concentrates / 中国输血杂志

ABSTRACT

Platelets concentrates play a vital role in the maintenance of normal hemostatic activity and the integrity of blood vessel wall. Accordingly, for patients with low platelet counts (thrombocytopenia) or dysfunction, platelet transfusion can be of significant value in preventing and treating hemorrhage. In recent years, various studies have proved that platelets also play a very important role on anti-inflammation and improvement of cell and tissue growth and repair in regeneration processes. Platelets with the natural source of various growth factors can help in wound healing and proliferation. At present, autologous platelet-rich plasma and platelet gel are also widely used in the treatment of clinical patients. Therefore, the non-transfusion therapy of allogeneic platelet concentrate and alternatives such as platelet rich plasma, platelet gel and dry platelet (freeze-dried platelet) should be applied on patients in the near future.