Clinical analysis of red blood cell transfusion in patients with bone marrow failure / 中国输血杂志

ABSTRACT

【Objective】 To explore the clinical factors affecting the efficacy of red blood cell (RBC) transfusion in patients with bone marrow failure diseases (BMFD). 【Methods】 81 patients with BMFD admitted to our hospital from June, 2012 to May, 2020 were analyzed retrospectively. Hemoglobin (Hb) was used as quantitative judgment basis, and multiple stepwise regression analysis was used to screen out various factors affecting the efficacy of red blood cell transfusion. 【Results】 229 occasions of RBC transfusion were performed in 81 patients, and 129 refractory transfusions occurred, accounting for 51.97%. The clinical effect of RBC transfusion is related to hemorrhage, hepatosplenomegaly, infection, blood transfusion frequency, anemia degree and BSA. Multiple stepwise regression analysis showed that infection, hemorrhage and blood transfusion frequency are important factors affecting the infusion effect. 【Conclusion】 The efficacy of RBC transfusion in BMFD patients is affected by various clinical factors. Clinicians should personalize the infusion strategy, so as to improve the transfusion efficacy by reducing the transfusion frequency, and bleeding as well as avoiding the transfusion during fever.