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Activated microglial cells synthesize and secrete AGE-albumin / 대한해부학회지
Anatomy & Cell Biology ; : 47-52, 2012.
Artigo em Inglês | WPRIM | ID: wpr-100674
ABSTRACT
A holy grail of curing neurodegenerative diseases is to identify the main causes and mechanisms underlying neuronal death. Many studies have sought to identify these targets in a wide variety of ways, but a more important task is to identify critical molecular targets and their origins. Potential molecular targets include advanced glycation end products (AGEs) that can promote neuronal cell death, thereby contributing to neurodegenerative disorders such as Alzheimer disease or Parkinson disease. In this study, we showed that AGE-albumin (glycated albumin) is synthesized in microglial cells and secreted in the human brain. Our results provide new insight into which microglial cells can promote the receptor for AGE-mediated neuronal cell death, eventually leading to neurodegenerative diseases.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doença de Parkinson / Encéfalo / Morte Celular / Microglia / Doenças Neurodegenerativas / Doença de Alzheimer / Neurônios Limite: Humanos Idioma: Inglês Revista: Anatomy & Cell Biology Ano de publicação: 2012 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Doença de Parkinson / Encéfalo / Morte Celular / Microglia / Doenças Neurodegenerativas / Doença de Alzheimer / Neurônios Limite: Humanos Idioma: Inglês Revista: Anatomy & Cell Biology Ano de publicação: 2012 Tipo de documento: Artigo