As sociation of Non-alcoholic Fatty Liver Disease with Metabolic Syndrome over 65 Years Elderly

ABSTRACT

BACKGROUND: The prevalence of non alcoholic fatty liver disease(NAFL) was increased by common use of abdominal ultrasonography and non alcoholic fatty liver disease has been associated metabolic syndrome. The aim of the present study was to evaluate the association of non alcoholic fatty liver disease with metabolic syndrome over 65 years elderly. METHOD: The subject of this study included 262 elderly aged 65 years or older who visited the Health Promotion Center of one university hospital, and the 42 non alcoholic fatty liver disease and the 220 normal control diagnosed by abdominal ultrasonography. We estimated the diagnosis of metabolic syndrome according to ATPlll guideline except Asia-Pacific waist circumference guideline. we evaluated the prevalence of non alcoholic fatty liver disease and the association of non alcoholic fatty liver disease with metabolic syndrome risk factors. We used the multiple logistic regression method to estimate odds ratios for metabolic syndrome of non alcoholic fatty liver disease and other risk factors. RESULTS: The prevalence of non alcoholic fatty liver disease was 16.0%. The mean values of waist circumference, HDL cholesterol, triglyceride, and fasting glucose were significantly increased in non alcoholic fatty liver disease compared with control subjects. The prevalence of abdominal obesity, hypertriglycemia, low HDL cholesterolemia, impaired fasting glucose was significantly increased in non alcoholic fatty liver disease compared with control subjects. Odds ratios of hypertriglycemia, low HDLcholesterolemia, and impaired fasting glucose on non alcoholic fatty liver disease were 2.18, 2.35, and 2.46 and were significantly associated. Odds ratio of non alcoholic fatty liver disease on metabolic syndrome was 2.32 and was significantly associated. CONCLUSION: The non alcoholic fatty liver disease was accompanied often in metabolic syndrome. This study suggested that life style modifications such as regular physical activity, weight reduction and diet were needed for management and treatment of non alcoholic fatty liver disease and metabolic syndrome.