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γδ T cells: Major advances in basic and clinical research in tumor immunotherapy / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 21-33, 2024.
Artigo em Inglês | WPRIM | ID: wpr-1007647
ABSTRACT
γδ T cells are a kind of innate immune T cell. They have not attracted sufficient attention because they account for only a small proportion of all immune cells, and many basic factors related to these cells remain unclear. However, in recent years, with the rapid development of tumor immunotherapy, γδ T cells have attracted increasing attention because of their ability to exert cytotoxic effects on most tumor cells without major histocompatibility complex (MHC) restriction. An increasing number of basic studies have focused on the development, antigen recognition, activation, and antitumor immune response of γδ T cells. Additionally, γδ T cell-based immunotherapeutic strategies are being developed, and the number of clinical trials investigating such strategies is increasing. This review mainly summarizes the progress of basic research and the clinical application of γδ T cells in tumor immunotherapy to provide a theoretical basis for further the development of γδ T cell-based strategies in the future.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Linfócitos T / Imunoterapia Adotiva / Receptores de Antígenos de Linfócitos T gama-delta / Imunoterapia / Neoplasias Limite: Humanos Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2024 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Linfócitos T / Imunoterapia Adotiva / Receptores de Antígenos de Linfócitos T gama-delta / Imunoterapia / Neoplasias Limite: Humanos Idioma: Inglês Revista: Chinese Medical Journal Ano de publicação: 2024 Tipo de documento: Artigo