The role of mitochondria-associated endoplasmic reticulum membranes in age-related cardiovascular diseases / 生理学报
Acta Physiologica Sinica
; (6): 799-816, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1007792
Biblioteca responsável:
WPRO
ABSTRACT
Mitochondria-associated endoplasmic reticulum membranes (MAMs) are the physical connection sites between mitochondria and endoplasmic reticulum (ER). As the compartments controlling substance and information communications between ER and mitochondria, MAMs were involved in the regulation of various pathophysiological processes, such as calcium homeostasis, mitochondrial morphology and function, lipid metabolism and autophagy. In the past decades, accumulating lines of evidence have revealed the pivotal role of MAMs in diverse cardiovascular diseases (CVD). Aging is one of the major independent risk factors for CVD, which causes progressive degeneration of the cardiovascular system, leading to increased morbidity and mortality of CVD. This review aims to summarize the research progress of MAMs in age-related CVD, and explore new targets for its prevention and treatment.
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Doenças Cardiovasculares
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Sinalização do Cálcio
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Retículo Endoplasmático
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Membranas Mitocondriais
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Mitocôndrias
Limite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2023
Tipo de documento:
Article