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Advances on the treatment of Fusobacterium nucleatum-promoted colorectal cancers using nanomaterials / 生物工程学报
Chinese Journal of Biotechnology ; (12): 3670-3680, 2023.
Artigo em Chinês | WPRIM | ID: wpr-1007984
ABSTRACT
Fusobacterium nucleatum (Fn) is an oral anaerobic bacterium that has recently been found to colonize on the surface of colorectal cancer cells in humans, and its degree of enrichment is highly negatively correlated with the prognosis of tumor treatment. Numerous studies have shown that Fn is involved in the occurrence and development of colorectal cancer (CRC), and Fn interacts with multiple components in the tumor microenvironment to increase tumor resistance. In recent years, researchers have begun using nanomedicine to inhibit Fn's proliferation at the tumor site or directly target Fn to treat CRC. This review summarizes the mechanism of Fn in promoting CRC and the latest research progress on Fn-related CRC therapy using different nanomaterials. Finally, the applications perspective of nanomaterials in Fn-promoted CRC therapy was prospected.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Filogenia / Composição de Bases / RNA Ribossômico 16S / Neoplasias Colorretais / Fusobacterium nucleatum / Análise de Sequência de DNA / Microambiente Tumoral Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Biotechnology Ano de publicação: 2023 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Filogenia / Composição de Bases / RNA Ribossômico 16S / Neoplasias Colorretais / Fusobacterium nucleatum / Análise de Sequência de DNA / Microambiente Tumoral Limite: Humanos Idioma: Chinês Revista: Chinese Journal of Biotechnology Ano de publicação: 2023 Tipo de documento: Artigo