Synthesis and application of the methyl analogues of S-adenosyl-L-methionine / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 4428-4444, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-1008034
ABSTRACT
Methylation plays a vital role in biological systems. SAM (S-adenosyl-L-methionine), an abundant cofactor in life, acts as a methyl donor in most biological methylation reactions. SAM-dependent methyltransferases (MTase) transfer a methyl group from SAM to substrates, thereby altering their physicochemical properties or biological activities. In recent years, many SAM analogues with alternative methyl substituents have been synthesized and applied to methyltransferases that specifically transfer different groups to the substrates. These include functional groups for labeling experiments and novel alkyl modifications. This review summarizes the recent progress in the synthesis and application of SAM methyl analogues and prospects for future research directions in this field.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
S-Adenosilmetionina
/
Racemetionina
/
Metionina
/
Metilação
/
Metiltransferases
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2023
Tipo de documento:
Artigo
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