Advances in the Role of Low-Dose Interleukin-2 in Immune-Mediated Dermatosis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 683-688, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-1008117
ABSTRACT
Immune-mediated dermatoses are the skin diseases caused by the breakdown of immune tolerance,including lupus erythematosus and dermatomyositis.The imbalance between regulatory T cells (Tregs) and effector T cells (Teffs) plays a key role in the pathogenesis of these diseases.Low-dose interleukin-2 can preferentially activate Tregs and reverse the imbalance between Tregs and Teffs to recover the immune tolerance,which has attracted attention in the treatment of immune-mediated dermatoses.This review summarizes the research progress in the immunomodulatory mechanism and clinical application of low-dose interleukin-2 in immune-mediated dermatoses,providing a new idea for the clinical treatment of these diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dermatopatias
/
Interleucina-2
/
Linfócitos T Reguladores
/
Lúpus Eritematoso Sistêmico
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Academiae Medicinae Sinicae
Ano de publicação:
2023
Tipo de documento:
Artigo
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