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TCR immune repertoire characteristics of patients with drug-induced liver injury due to Polygonum multiflorum preparations / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 4397-4404, 2019.
Artigo em Chinês | WPRIM | ID: wpr-1008205
ABSTRACT
To explore the immune status of patients with drug-induced liver injury caused by Polygonum multiflorum preparations,and analyze their immune characteristics. Case-control design was used to collect the cases of drug-induced liver injury caused by P. multiflorum preparations through key specialized surveillance. Five matching factors,namely type of P. multiflorum preparations,gender,age,basic diseases and concomitant medication were controlled. According to the ratio of 1 ∶ 1,cases of patients who took P. multiflorum preparations but with no liver injury were monitored at prospective hospitals. The demographic information,disease information,medication information and laboratory examination information of the two groups were recorded,and venous blood was collected. The gene sequence was detected by high-throughput sequencing technology,and the characteristics of TCR immune repertoire of the two groups were analyzed. A total of 46 pairs of patients were enrolled in the study. The results showed significant differences in the number of CDR3 and clone species,the length of amino acid sequence in CDR3 region,the abundance of V gene and J gene,the cross-linking of V-J gene and the diversity of immune repertoire between patients with drug-induced liver injury and patients without liver injury. The immunohistochemical diversity and high-frequency V-J cross-linking characteristics of patients with liver injury caused by P. multiflorum preparations were found,which provided a reference for screening out drug users to reduce the occurrence of liver injury caused by P. multiflorum preparations.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medicamentos de Ervas Chinesas / Receptores de Antígenos de Linfócitos T / Estudos Prospectivos / Polygonum / Doença Hepática Induzida por Substâncias e Drogas / Fallopia multiflora Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2019 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Medicamentos de Ervas Chinesas / Receptores de Antígenos de Linfócitos T / Estudos Prospectivos / Polygonum / Doença Hepática Induzida por Substâncias e Drogas / Fallopia multiflora Limite: Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2019 Tipo de documento: Artigo