Evaluation of key production processes of Schizonepetae Herba formula granules based on characteristic chromatogram and quantitative transfer relationship / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1357-1362, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-1008579
ABSTRACT
The aim of this paper was to evaluate the key production processes of Schizonepetae Herba formula granules based on the new model of combining characteristic chromatogram with quantitative transfer relationship. The rationality of production process design was evaluated by studying the intermediates in different processes of formula granules, analyzing the loss of index component pulegone in each step, and establishing the characteristic chromatogram. The content of pulegone in 10 batches of standard decoction ranged between 0.067% and 0.124%(70%-130% of the average value), and the transfer rate of pulegone was 44.58%-93.97%. After the improvement of the production process, the content of pulegone in Schizonepetae Herba formula granules was 0.093%, and the transfer rate of pulegone was 68.38%, which was consistent with the parameters range of standard decoction. This study emphasized the integrality of the research process of traditional Chinese medicine(TCM) formula granules, and provided a new idea for the quality control of TCM with content determination as the main evaluation index for a long time.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Controle de Qualidade
/
Medicamentos de Ervas Chinesas
/
Cromatografia Líquida de Alta Pressão
/
Lamiaceae
/
Medicina Tradicional Chinesa
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2020
Tipo de documento:
Artigo
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