Three new cucurbitane-type triterpenoid glycosides from Citrullus colocynthis and their anti-inflammatory activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 4124-4129, 2023.
Article
em Zh
| WPRIM
| ID: wpr-1008608
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WPRO
ABSTRACT
Three new cucurbitane-type triterpenoid glycosides were separated from the ethyl acetate extract of Citrullus colocynthis by a variety of chromatographic techniques. According to the data of NMR, HR-ESI-MS, and/or comparison with the reported data, the three novel cucurbitane-type triterpenoid glycosides were identified as colocynthenin E(1), colocynthenin G(2), and colocynthenin H(3). The cell inflammation model was established with RAW264.7 macrophages exposed to lipopolysaccharide and then used to determine the anti-inflammatory activities of the three compounds. Compounds 2 and 3 showed mild anti-inflammatory activities with the IC_(50) of 48.21 and 40.11 μmol·L~(-1), respectively, compared with that(IC_(50)=7.57 μmol·L~(-1)) of the positive control dexamethasone.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Triterpenos
/
Extratos Vegetais
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Citrullus colocynthis
/
Glicosídeos
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Anti-Inflamatórios
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2023
Tipo de documento:
Article