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Advances in mechanism of traditional Chinese medicine in inhibiting angiogenesis in ovarian cancer / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 6572-6581, 2023.
Artigo em Chinês | WPRIM | ID: wpr-1008856
ABSTRACT
Ovarian cancer is one of the three major cancers in gynecology. Ovarian cancer has insidious symptoms in its early stages and mostly has progressed to advanced stages when detected. Surgical treatment combined with chemotherapy is currently the main treatment, but the 5-year survival rate is still less than 45%. Angiogenesis is a key step in the growth and metastasis of ovarian cancer. The inhibition of ovarian cancer angiogenesis has become a new hotspot in anti-tumor targeted therapy, which has many advantages such as less drug resistance, high specificity, few side effects, and broad anti-tumor spectrum. Modern research has confirmed that traditional Chinese medicine(TCM) can inhibit tumor angiogenesis by inhibiting the expression of pro-angiogenic factors, up-regulating the expression of anti-angiogenic factors, inhibiting the proliferation of vascular endothelial cells, reducing the density of tumor microvessels, and regulating related signaling pathways, with unique advantages in the treatment of ovarian cancer. This paper presented a review of the role of TCM in inhibiting ovarian cancer angiogenesis in order to provide references for the optimization of clinical ovarian cancer treatment strategies.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Ovarianas / Inibidores da Angiogênese / Células Endoteliais / Fator A de Crescimento do Endotélio Vascular / Angiogênese / Medicina Tradicional Chinesa / Neovascularização Patológica Limite: Feminino / Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2023 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Ovarianas / Inibidores da Angiogênese / Células Endoteliais / Fator A de Crescimento do Endotélio Vascular / Angiogênese / Medicina Tradicional Chinesa / Neovascularização Patológica Limite: Feminino / Humanos Idioma: Chinês Revista: China Journal of Chinese Materia Medica Ano de publicação: 2023 Tipo de documento: Artigo