The role of natural killer cells in anti-infection and tumor therapy / 细胞与分子免疫学杂志
Chinese Journal of Cellular and Molecular Immunology
;
(12): 952-958, 2023.
Artigo
em Chinês
| WPRIM
| ID: wpr-1009453
ABSTRACT
Natural killer (NK) cells are an important part of the body's innate immune system. As the first line of defense against pathogens, they need to be transformed into a mature state under the control of various cell signaling molecules and transcription factors to play cytotoxic and immune regulatory roles. Under the interaction of activated receptors and inhibitory receptors, NK cells are activated to perform a direct cell killing effect by secreting perforin and granzyme, or indirectly eliminate pathogenic microorganisms in the body by secreting various cytokines, such as type I and type II interferons. These functions of NK cells play a very important role in antiviral and anti-autoimmune diseases, especially in anti-tumor.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Autoimunes
/
Células Matadoras Naturais
/
Citocinas
/
Interferon gama
/
Apoptose
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Cellular and Molecular Immunology
Ano de publicação:
2023
Tipo de documento:
Artigo
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