Impact of taxanes on androgen receptor signaling / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 249-252, 2019.
Artigo
em Inglês
| WPRIM
| ID: wpr-1009621
ABSTRACT
The development and progression of metastatic castration-resistant prostate cancer is the major challenge in the treatment of advanced prostate cancer. The androgen receptor signaling pathway remains active in metastatic castration-resistant prostate cancer. Docetaxel and cabazitaxel are the first- and second-line chemotherapy, respectively, for patients with metastatic castration-resistant prostate cancer. These two taxanes, in general, function by (i) inhibiting mitosis and inducing apoptosis and (ii) preventing microtubule-dependent cargo trafficking. In prostate cancer, taxanes have been reported to inhibit the nuclear translocation and activity of the androgen receptor. However, whether this is attainable or not clinically remains controversial. In this review, we will provide a comprehensive view of the effects of taxanes on androgen receptor signaling in prostate cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transdução de Sinais
/
Receptores Androgênicos
/
Taxoides
/
Neoplasias de Próstata Resistentes à Castração
/
Antineoplásicos Fitogênicos
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2019
Tipo de documento:
Artigo
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