Prognostic role of chromogranin A in castration-resistant prostate cancer: A meta-analysis / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 561-566, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-1009640
ABSTRACT
We aimed to investigate the prognostic value of chromogranin A (CgA) in castration-resistant prostate cancer (CRPC). We conducted a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described CgA and CRPC and performed a standard meta-analysis on survival outcomes. Our meta-analysis included eight eligible studies with 686 patients. The results were as follows progression-free survival (PFS) was associated with CgA level (hazard ratio [HR] = 2.47, 95% confidence interval [CI] 1.47-4.14, P = 0.0006); PFS was relative to CgA change (HR = 9.22, 95% CI 3.03-28.05, P < 0.0001); and overall survival (OS) was relative to CgA level (HR = 1.47, 95% CI 1.15-1.87, P = 0.002). When we divided the patients into two groups according to therapy status, the result for OS relative to CgA level was an HR of 1.26 (95% CI 1.09-1.45, P = 0.001) in the first-line hormonal therapy group, and an HR of 2.33 (95% CI 1.40-3.89, P = 0.001) in the second-line hormonal therapy or chemotherapy group. This meta-analysis indicated that a high CgA level had a negative influence on OS and PFS in CRPC patients. In addition, CRPC patients with a rising CgA had a shorter PFS. Further studies are needed to verify the prognostic value of CgA in CRPC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Análise de Sobrevida
/
Valor Preditivo dos Testes
/
Reprodutibilidade dos Testes
/
Cromogranina A
/
Neoplasias de Próstata Resistentes à Castração
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2018
Tipo de documento:
Artigo
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