Research Progress of Granulocytic Myeloid-derived Suppressor Cells
in Non-small Cell Lung Cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 65-72, 2024.
Article
em Zh
| WPRIM
| ID: wpr-1010111
Biblioteca responsável:
WPRO
ABSTRACT
Granulocytic myeloid-derived suppressor cells (G-MDSCs) are one of the main subgroups of MDSCs, which are widely enriched in most cancers. It can inhibit the killing function of T-lymphocyte through the expression of arginase-1 (Arg-1) and reactive oxygen species (ROS), reshape the tumor immune microenvironment, and promote the occurrence and development of tumors. In recent years, more and more studies have found that G-MDSCs are significantly correlated with the prognosis and immunotherapy efficacy of patients with non-small cell lung cancer, and the use of drugs specifically targeting the recruitment, differentiation and function of G-MDSCs can effectively inhibit tumor progression. This article reviews the immunosuppressive effect of G-MDSCs in non-small cell lung cancer and the progress of related pathway targeting drugs.
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Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Linfócitos T
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Carcinoma Pulmonar de Células não Pequenas
/
Microambiente Tumoral
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Células Supressoras Mieloides
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Imunoterapia
/
Neoplasias Pulmonares
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Lung Cancer
Ano de publicação:
2024
Tipo de documento:
Article