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In vitro antioxidant activity of phenolic-enriched extracts from Zhangping Narcissus tea cake and their inhibition on growth and metastatic capacity of 4T1 murine breast cancer cells / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B ; (12): 199-210, 2018.
Artigo em Inglês | WPRIM | ID: wpr-1010380
ABSTRACT
Phenolics, as the main bioactive compounds in tea, have been suggested to have potential in the prevention of various human diseases. However, little is known about phenolics and their bioactivity in Zhangping Narcissue tea cake which is considered the most special kind of oolong tea. To unveil its bioactivity, three phenolic-enriched extracts were obtained from Zhangping Narcissue tea cake using ethyl acetate, n-butanol, and water. Their main chemical compositions and in vitro bioactivity were analyzed by high-performance liquid chromatography (HPLC) and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS). The ethyl acetate fraction (ZEF) consisted of higher content of phenolics, flavonoids, procyanidins, and catechin monomers (including epigallocatechin gallate (EGCG), epicatechin gallate (ECG), and gallocatechin gallate (GCG)) than n-butanol fraction (ZBF) and water fraction (ZWF). ZEF exhibited the strongest antioxidant capacity in vitro due to its abundant bioactive compounds. This was validated by Pearson correlation and hierarchical clustering analyses. ZEF also showed a remarkable inhibition on the growth, migration, and invasion of 4T1 murine breast cancer cells.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenóis / Extratos Vegetais / Movimento Celular / Camellia sinensis / Linhagem Celular Tumoral / Proliferação de Células / Neoplasias Mamárias Experimentais / Metástase Neoplásica / Antineoplásicos Fitogênicos / Antioxidantes Limite: Animais Idioma: Inglês Revista: Journal of Zhejiang University. Science. B Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenóis / Extratos Vegetais / Movimento Celular / Camellia sinensis / Linhagem Celular Tumoral / Proliferação de Células / Neoplasias Mamárias Experimentais / Metástase Neoplásica / Antineoplásicos Fitogênicos / Antioxidantes Limite: Animais Idioma: Inglês Revista: Journal of Zhejiang University. Science. B Ano de publicação: 2018 Tipo de documento: Artigo