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Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 1497-1511, 2023.
Article em En | WPRIM | ID: wpr-1010637
Biblioteca responsável: WPRO
ABSTRACT
Chronic cerebral hypoperfusion leads to white matter injury (WMI), which subsequently causes neurodegeneration and even cognitive impairment. However, due to the lack of treatment specifically for WMI, novel recognized and effective therapeutic strategies are urgently needed. In this study, we found that honokiol and magnolol, two compounds derived from Magnolia officinalis, significantly facilitated the differentiation of primary oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes, with a more prominent effect of the former compound. Moreover, our results demonstrated that honokiol treatment improved myelin injury, induced mature oligodendrocyte protein expression, attenuated cognitive decline, promoted oligodendrocyte regeneration, and inhibited astrocytic activation in the bilateral carotid artery stenosis model. Mechanistically, honokiol increased the phosphorylation of serine/threonine kinase (Akt) and mammalian target of rapamycin (mTOR) by activating cannabinoid receptor 1 during OPC differentiation. Collectively, our study indicates that honokiol might serve as a potential treatment for WMI in chronic cerebral ischemia.
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Texto completo: 1 Índice: WPRIM Assunto principal: Isquemia Encefálica / Oligodendroglia / Magnolia / Substância Branca Idioma: En Revista: Neuroscience Bulletin Ano de publicação: 2023 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Assunto principal: Isquemia Encefálica / Oligodendroglia / Magnolia / Substância Branca Idioma: En Revista: Neuroscience Bulletin Ano de publicação: 2023 Tipo de documento: Article