Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1 axis / 医学前沿
Frontiers of Medicine
; (4): 924-938, 2023.
Article
em En
| WPRIM
| ID: wpr-1010807
Biblioteca responsável:
WPRO
ABSTRACT
Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multiple cancers. However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear. In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors. Gain- and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasis of ovarian cancer cells in vivo and in vitro. Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis. Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling. Collectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer, which may be a potential prognostic biomarker.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Neoplasias Ovarianas
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Regulação Neoplásica da Expressão Gênica
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Movimento Celular
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MicroRNAs
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Linhagem Celular Tumoral
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Proteínas Adaptadoras de Transdução de Sinal
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Proliferação de Células
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RNA Longo não Codificante
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RNA Endógeno Competitivo
Limite:
Female
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Humans
Idioma:
En
Revista:
Frontiers of Medicine
Ano de publicação:
2023
Tipo de documento:
Article