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Phase separation in cGAS-STING signaling / 医学前沿
Frontiers of Medicine ; (4): 855-866, 2023.
Artigo em Inglês | WPRIM | ID: wpr-1010821
ABSTRACT
Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Transdução de Sinais / Separação de Fases / Proteínas de Membrana / Nucleotidiltransferases Limite: Humanos Idioma: Inglês Revista: Frontiers of Medicine Ano de publicação: 2023 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Transdução de Sinais / Separação de Fases / Proteínas de Membrana / Nucleotidiltransferases Limite: Humanos Idioma: Inglês Revista: Frontiers of Medicine Ano de publicação: 2023 Tipo de documento: Artigo