Discovery and bioassay of disubstituted β-elemene-NO donor conjugates: synergistic enhancement in the treatment of leukemia / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 916-926, 2023.
Article
em En
| WPRIM
| ID: wpr-1011003
Biblioteca responsável:
WPRO
ABSTRACT
Natural products are essential sources of antitumor drugs. One such molecule, β-elemene, is a potent antitumor compound extracted from Curcuma wenyujin. In the present investigation, a series of novel 13,14-disubstituted nitric oxide (NO)-donor β-elemene derivatives were designed, with β-elemene as the foundational compound, and subsequently synthesized to evaluate their therapeutic potential against leukemia. Notably, the derivative labeled as compound 13d demonstrated a potent anti-proliferative activity against the K562 cell line, with a high NO release. In vivo studies indicated that compound 13d could effectively inhibit tumor growth, exhibiting no discernible toxic manifestations. Specifically, a significant tumor growth inhibition rate of 62.9% was observed in the K562 xenograft tumor mouse model. The accumulated data propound the potential therapeutic application of compound 13d in the management of leukemia.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Sesquiterpenos
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Bioensaio
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Leucemia
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Doadores de Óxido Nítrico
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Linhagem Celular Tumoral
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Proliferação de Células
Limite:
Animals
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Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Ano de publicação:
2023
Tipo de documento:
Article