Evaluation of Maternal Toxicity in Rats Exposed to Multi-Wall Carbon Nanotubes during Pregnancy
Environmental Health and Toxicology
;
: e2011006-2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-101240
ABSTRACT
OBJECTIVES:
The present study investigated the potential adverse effects of multi-wall carbon nanotubes (MWCNTs) on pregnant dams and embryonic development following maternal exposure in rats.METHODS:
MWCNTs were orally administered to pregnant rats from gestational day (GD) 6 through 19 at dose levels of 0, 8, 40, 200, and 1000 mg/kg/day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, oxidant-antioxidant status, gross findings, organ weights, and Caesarean section findings were examined.RESULTS:
All animals survived to the end of the study. A decrease in thymus weight was observed in the highest dose group. However, maternal body weight, food consumption, serum biochemical parameters, and oxidant-antioxidant balance in the kidneys were not affected by treatment with MWCNTs. No treatment-related differences in gestational index, embryo-fetal mortality, or fetal and placental weights were observed between treated and control groups.CONCLUSIONS:
The results show that 14-day repeated oral dosing of MWCNTs during pregnancy induces minimal maternal toxicity at 1000 mg/kg/day in rats. Under these experimental conditions, the no-observed-adverse-effect level of MWCNTs is considered to be 200 mg/kg/day for dams and 1000 mg/kg/day for embryonic development.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tamanho do Órgão
/
Timo
/
Pesos e Medidas
/
Bioquímica
/
Peso Corporal
/
Carbono
/
Cesárea
/
Estresse Oxidativo
/
Exposição Materna
/
Nível de Efeito Adverso não Observado
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Environmental Health and Toxicology
Ano de publicação:
2011
Tipo de documento:
Artigo
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