Research strategies and frontier technology advances in intracerebral pharmacokinetics / 中国药理学通报

ABSTRACT

The establishment of the cerebral pharmacokinetic model aims to truly reflect the disposition and course of action of drugs entering brain tissues, to ensure that brain-targeted drugs reach effective intracerebral concentrations, while preventing neurological damage from non-brain-targeted drugs, and to greatly improve effectiveness and safety. With the rapid development of research strategies and analytical techniques in the field of pharmacokinetics, intracerebral pharmacokinetic techniques have evolved from traditional brain tissue homogenization and cerebrospinal fluid extraction to in situ in vivo analysis techniques, from invasive techniques to non-invasive imaging techniques, and from the macroscopic tissue level to the microscopic cellular/subcellular level. A variety of pharmacokinetic research methods in brain are complementing each other and becoming increasingly perfect, gradually forming a comprehensive " subcellular-cellular-tissue" pharmacokinetic research system in brain, laying the foundation for elucidating the dynamic changes of drugs in brain and predicting the course of action of drugs in brain. This paper reviews the evolution and development of pharmacokinetic research strategies in brain, evaluates the advantages and limitations of various techniques and methods, and provides a reference for predicting the pharmacodynamic and toxic effects of drugs in brain tissues.