Research progress on central neurotoxicity mechanism and prevention of trimethyltin chloride / 中国药理学通报

ABSTRACT

Trimethyltin chloride is a highly toxic by-product produced during the process of synthesizing polyvinyl chloride plastics. It has specially central neurotoxicity, which is mainly manifested as inducing the death of neurons in human and animal central nervous system, especially hippocampal neurons. TMT poisoning can cause seizures, diarrhea, learning and memory impairment and other clinical manifestations, and even coma or death in severe cases. In order to better understand the role of TMT neurotoxicity in central nerve system, this paper reviews the research progress on both the molecular mechanism and therapeutic drugs of central neurotoxicity caused by TMT, thereby providing new ideas for the prevention and treatment of TMT-in-duced neurotoxicity.