Animal models of acute plateau disease / 中国药理学通报

ABSTRACT

Acute plateau disease refers to a variety of physiological and pathological reactions produced by the body in a short period of time after rapidly advancing into the high-pressure and low-oxygen plateau area with an altitude above 2 500 meters, mainly including acute mountain sickness (AMS), high altitude pulmonary edema (HAPE) and high altitude cerebral edema (H A C E), which seriously affects the health of people in the acute plateau and even threats their lives. The establishment of an animal model of acute plateau disease with good reproducibility and a sound evaluation system are the basis of the research on acute plateau disease. Acute plateau disease is mainly caused by the low oxygen conditions on the plateau, so the animal model of acute plateau disease can be established in plateau environment simulation cabin or plateau field, simple breeding or animal treadmill assisted sports training. The indicators that indicate the success of the model establishment are commonly used blood gas, inflammation factors, organizational water content and pathological section. In this article, the animal models of acute plateau disease established in recent years are reviewed from the aspects of modeling environment, modeling methods and evaluation indicators.