Study on advances of tumor metabolites mediating immune escape and angiogenesis / 中国药理学通报

ABSTRACT

The progression of tumor is a dynamic process of multiple factors interacting with each other. With its unique metabolic method, tumor cells meet their own rapid proliferation needs while promoting inhibitory immune cell infiltration and tumor angiogenesis, thereby affecting tumor immune escape, promoting tumor metastasis. Abnormal glucose, lipids, amino acids and energy metabolites of tumor cells are closely related to immune abnormalities and vascular diseases, which are the research hotspots in this field in recent years. This article reviews the effects of tumor metabolites on tumor immunity and pathological angiogenesis and its molecular mechanisms, which provides the potential targets for tumor therapy with metabolism as a target.